Susmitha Shankar

This study identifies Gid11 as a substrate receptor for the GID ubiquitin ligase in budding yeast, revealing its role in regulating metabolic transitions by targeting glycolytic factors during ethanol metabolism.

The paper constructs genome-wide conditional degron libraries in yeast to improve functional genomics by enabling controlled protein degradation and avoiding suppressor mutations.

The paper identifies over 5000 C-degrons in budding yeast and shows that the SCF ubiquitin ligase targets ~40% of them via the F-box receptor Das1.

This study predicts adverse drug reactions from two-drug combinations using structural and transcriptomic data in an artificial neural network, achieving 82% average accuracy.

PROTEINATOR identifies indirect drug interactions for proteins by integrating databases to find potential modulators through protein-protein interactions.