This study shows that modulating autophagy with rapamycin improves survival and reduces intestinal injury after radiation, while chloroquine worsens it.

bioRxiv · Jul 6, 2026 · PreprintMolecular Biology

Aberrant inheritance of extrachromosomal DNA amplifications promotes cancer evolution

Shir Marom, I. DAYAN, Venkata Narasimha Kadali, Mădălina Giurgiu, Gabriela Koifman, Karen Hakeny, Madhuri Chaurasia, Orléna Benamozig, Reinat Nevo, Ido Azuri, Julia Ryvkin, Ron Rotkopf, Gil Stelzer, Nino Oniashvili, Jacques Mardoukh, , Ofer Shoshani

The paper investigates how extrachromosomal DNA (ecDNA) inheritance mechanisms influence cancer evolution through mitotic segregation and micronuclei formation.

bioRxiv · Sep 19, 2025 · PreprintCancer Biology

TECPR2 maintains mitochondrial homeostasis in neurodegeneration

Madhuri Chaurasia, Milana Fraiberg, Nemanja Subic, Oren Shatz, Kamilya Kokabi, Olee Gogoi, Olena Trofimyuk, Bat Chen Tamim-Yecheskel, Saskia Freud, Alik Demishtein, Ekaterina Kopitman, Inna Goliand, Sabita Chourasia, Yoav Peleg, Elena Ainbinder, , Zvulun Elazar

This study shows that TECPR2 loss causes mitochondrial dysfunction and mitophagy impairment in HSAN9, which can be mitigated by ISR suppression.

bioRxiv · Sep 4, 2025 · PreprintCell Biology