Iddo Paldor

The paper profiles microRNA expression in human brain cell types to reveal cell-type specificity and age-related changes.

This study establishes an ex vivo brain slice culture platform to study glial cell responses and multicellular communication in adult human brain tissue.

This study shows that Klotho knockout affects brain microRNAs and tRNA fragments linked to aging and Alzheimer's disease in both mice and humans.

This study identifies LysTTT-5tRF and miR-194-5p as co-regulators of hepatic steatosis through beta-Klotho and Perilipin 2, showing their cooperative roles in lipid metabolism.

The paper identifies sex-specific changes in cholinergic-targeting tRNA fragments in Alzheimer's disease, linking them to cholinergic neuron loss and dementia.

The paper examines tRF levels in CSF and blood across age, sex, and Parkinson's disease, finding distinct patterns and suggesting their potential as biomarkers.