The paper measures all-trans retinoic acid (atRA) concentrations in mice and develops a model to understand its transport and role in myopia development.

Journal of The Royal Society Interface · Sep 1, 2025Peer-reviewedBioengineering

Mechanism by which Aurora B inhibitors promotes RB and p53-dependent senescence.

Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina A. Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew V. Jones, Yaowu He, John David Hooper, Nigel A.J. McMillan, Jelena Urosevic, Jamal Carlos Saeh, , Brian G. Gabrielli

This study investigates how Aurora B inhibitors induce polyploidy and shows that higher ploidy states reduce long-term proliferative potential in cells with functional RB and p53.

Cell Death and Disease · Jan 8, 2025Peer-reviewedCell Biology

Studies of all-trans retinoic acid transport in myopigenesis

Saptarshi Chatterjee, Ankana Roy, Jianshi Yu, A. Thomas Read, Melissa R. Bentley‐Ford, Machelle T. Pardue, Maureen A. Kane, M. G. Finn, C. Ross Ethier

This study evaluates a fluorescent analog of all-trans retinoic acid as a surrogate for studying its transport and distribution in ocular tissues.

bioRxiv · Jan 4, 2025 · PreprintBiochemistry

Differential expression of single-cell RNA-seq data using Tweedie models

Himel Mallick, Suvo Chatterjee, Shrabanti Chowdhury, Saptarshi Chatterjee, Ali Rahnavard, Stephanie C. Hicks

The paper introduces Tweedie models for differential expression analysis in scRNA-seq, showing improved performance over existing methods across platforms.

Statistics in Medicine · Jun 2, 2022Peer-reviewedBioinformatics