Synthetic BiologybioRxivPreprint
HP1-enhanced chromatin compaction stabilizes a synthetic metabolic circuit in yeast
Lidice González, Sergio A. García Echauri, Celia Jerónimo…·Stephen W. Michnick
This paper shows that expressing HP1 homologues in yeast increases chromatin compaction, reducing mutation and recombination rates, and improving the stability of synthetic metabolic circuits.
DOI 10.1101/2025.03.04.641524