Stephen W. Michnick

SARS-CoV-2 maturation driven by a mechano-active nucleocapsid-RNA condensate

This study shows that SARS-CoV-2 maturation involves N protein-vgRNA condensates that are selectively enveloped by membranes due to RNA-dependent material properties.

HP1-enhanced chromatin compaction stabilizes a synthetic metabolic circuit in yeast

This paper shows that expressing HP1 homologues in yeast increases chromatin compaction, reducing mutation and recombination rates, and improving the stability of synthetic metabolic circuits.

A strategy for genome-wide seamless tagging of human protein-coding genes

The paper introduces a CRISPR-based method to tag human protein-coding genes, achieving 36% tagging efficiency in HEK 293T cells.

Protein-protein interaction is a major source of epistasis in genetic interaction networks

The paper shows that genetic interactions correlate with protein-protein interactions in yeast and human genomes, and that GI and PPI networks share overlapping topological features.

Genetic landscape of an in vivo protein interactome

The paper maps genetic variation's effect on protein-protein interactions in yeast, finding trans-acting SNPs have larger effects than cis-acting ones and SNPs in non-coding regions are significant.

A Yeast Global Genetic Screen Reveals that Metformin Induces an Iron Deficiency-Like State

The paper uses hdPCA to identify gene functions and pathways affected by metformin, revealing an iron deficiency-like cellular response.