This study identifies cell type-specific DNA methylation associations with childhood ADHD symptoms using deconvolution and sequencing-based methylation data from peripheral and cord blood.

European Neuropsychopharmacology · Oct 26, 2025Peer-reviewedGenetic & Genomic Medicine

Adolescent chronic sleep restriction promotes alcohol drinking in adulthood: evidence from epidemiological and preclinical data.

Oluwatomisin Olalekan Faniyan, Daniele Marcotulli, Reyila Simayi, Federico Del Gallo, Sara De Carlo, Eleonora Ficiarà, Doretta Caramaschi, Rebecca Claire Richmond, Daniela Franchini, Michele Bellesi, Roberto Ciccocioppo, Luisa de Vivo

This study shows that adolescent sleep restriction increases adult alcohol consumption by promoting risky behavior, using both human epidemiological data and preclinical experiments.

bioRxiv · Oct 11, 2023 · PreprintNeuroscience

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.

Doretta Caramaschi, Alexander Neumann, Andrés Cárdenas, Gwen N. Tindula, Silvia Alemany, Lea Zillich, Giancarlo Pesce, Jari M. T. Lahti, Alexandra Havdahl, Rosa H. Mulder, Janine F. Felix, Henning W. Tiemeier, Lea Sirignano, Josef Frank, Stephanie H. Witt, , Gemma C. Sharp

This study examines DNA methylation at birth and its association with childhood cognitive skills, finding weak single CpG site associations and one region near DUSP22 linked to non-verbal cognition.

Molecular Psychiatry · Feb 10, 2022Peer-reviewedDevelopmental Biology

Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis

Alexander Neumann, Esther Walton, Silvia Alemany, Charlotte A. M. Cecil, Juan R. González, Dereje D. Jima, Jari M. T. Lahti, Samuli Tuominen, Edward Dylan Barker, Elisabeth B. Binder, Doretta Caramaschi, Ángel Carracedo, Darina Czamara, Jorunn Evandt, Janine F. Felix, , Henning W. Tiemeier

This study identifies DNA methylation sites at birth associated with ADHD symptoms later in childhood, but finds no such associations at school age.

Translational Psychiatry · Nov 12, 2020Peer-reviewedGenetics

Association between breastfeeding and DNA methylation over the life course: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Fernando Pires Hartwig, George Davey Smith, Andrew J. Simpkin, Cesar Gomes Victora, Caroline Laura Relton, Doretta Caramaschi

This study investigates the association between breastfeeding and DNA methylation changes in children and adolescents using data from the ALSPAC cohort, finding some consistent methylation sites linked to breastfeeding at ages 7 and 15-17.

Nutrients · Oct 29, 2020Peer-reviewedGenetics