Cancer BiologybioRxivPreprint
Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.
Shiqi Diao, Jia Yi Zou, Shuo Wang…·Antonis E. Koromilas
This study shows that activation of the integrated stress response (ISR) drives tumor evolution and therapy resistance by promoting dedifferentiation and stemness in lung adenocarcinoma.
6 citations