Author

Hyungdong Kim

Jewish General HospitalORCID 0000-0002-8003-2189Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Antonis E. KoromilasiD· 3 shared Jia Yi ZouiD· 3 shared Shiqi DiaoiD· 3 shared Maria HatzoglouiD· 2 shared Nahum SonenbergiD· 2 shared Nour Ghaddar· 2 shared Peter WalteriD· 2 shared Atsuo T. SasakiiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Antonis E. KoromilasORCID

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3 papers

Recent·Most cited

eIF2B Selectively Anchors and Activates Mutant KRAS

Hyungdong Kim, Shiqi Diao, Kwang‐Jin Cho, Hyun-Ro Lee, Junchen Liu, Pascal F. Egea, Tatu Pantsar, Milla Kurki, Nour Ghaddar, Shuo Wang, Jia Yi Zou, Mehdi Amiri, Ritchel B. Gannaban, John F. Hancock, Kylie M. Rice, , Antonis E. Koromilas

This paper shows eIF2B activates mutant KRAS by forming a complex with SOS at the plasma membrane and regulating glycosphingolipid biosynthesis.

bioRxiv · Nov 10, 2025 · PreprintCancer Biology

A feedforward loop between STAT1 and YAP1 stimulates lipid biosynthesis, accelerates tumor growth, and promotes chemotherapy resistance in mutant KRAS colorectal cancer.

Shuo Wang, Shiqi Diao, Hyungdong Kim, Jia Yi Zou, Ke Ke Li, Antonis E. Koromilas

Communications Biology · Aug 25, 2025Peer-reviewedCancer Biology

Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

Shiqi Diao, Jia Yi Zou, Shuo Wang, Nour Ghaddar, Jason Earl Chan, Hyungdong Kim, Nicolas Poulain, Constantinos Koumenis, Maria Hatzoglou, Peter Walter, Nahum Sonenberg, John P. C. Le Quesne, Tuomas Tammela, Antonis E. Koromilas

This study shows that activation of the integrated stress response (ISR) drives tumor evolution and therapy resistance by promoting dedifferentiation and stemness in lung adenocarcinoma.

bioRxiv · Feb 10, 2025 · PreprintCancer Biology