Author

Rebecca J. Freeman

Boston Children's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

Leonard Ira ZoniD· 2 shared Samuel J. WattrusiD· 2 shared Song P. YangiD· 2 shared Alejo Rodriguez-FraticelliiD· 1 shared Alena KroupovaiD· 1 shared Alessio CiulliiD· 1 shared Alex Maya Pombo· 1 shared Alexander van OudenaardeniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

Leonard Ira ZonORCID

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Author profile →

3 papers

Recent·Most cited

A method for the detection and enrichment of endogenous cereblon substrates

Hannah C. Lloyd, Yuli Li, N. Connor Payne, Zhenguang Zhao, Wenqing Xu, Alena Kroupova, David Zollman, Tengfang Long, Farah Kabir, Mei Chen, Rebecca J. Freeman, Ethan Yang Feng, Sarah Y Xi, Ya-Chieh Hsu, Alessio Ciulli, , Christina M. Woo

This paper introduces a method called cerebody to detect and enrich endogenous cereblon substrates by targeting C-terminal cyclic imide modifications.

Cell Chemical Biology · Aug 1, 2025Peer-reviewedBiochemistry

A molecular switch: Ro5-3335 drives hematopoietic stem cell division and clonality through distinct RUNX1 binding partners

Anne L. Robertson, Yue Lü, Avik Choudhuri, Daniel Fernández-Pérez, Alex Maya Pombo, Caroline Kubaczka, Samuel J. Wattrus, Kyle D. Drake, Joseph Mandelbaum, Serine Avagyan, Song P. Yang, Rohan Bhattacharya, Rebecca J. Freeman, Victoria Chan, Megan C. Blair, , Leonard Ira Zon

This study identifies Ro5-3335 as a chemical that increases HSC clone number and clonal diversity by altering RUNX1 binding partners in zebrafish and mouse models.

bioRxiv · Jun 7, 2024 · PreprintCell Biology

Transcription factor induction of vascular blood stem cell niches in vivo

Elliott J. Hagedorn, Julie R. Perlin, Rebecca J. Freeman, Samuel J. Wattrus, Tianxiao Han, Clara Mao, Ji Wook Kim, Inés Fernández-Maestre, Madeleine L. Daily, Christopher R. D'Amato, Michael J. Fairchild, Raquel Riquelme, Brian Li, Dana A.V.E. Ragoonanan, Khaliun Enkhbayar, , Leonard Ira Zon

This study identifies transcription factors that induce vascular blood stem cell niches in vivo, enabling synthetic niche generation and potential therapeutic applications.

Developmental Cell · Apr 28, 2023Peer-reviewedDevelopmental Biology