Author

Jian Zhang

Howard Hughes Medical InstituteORCID 0000-0001-8799-3444Unclaimed ORCID profile · follow to get notified of new preprints

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Jian Zhang12 papers · Southern University of Science and Technology

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Filip BoškovićiD· 2 shared Jack W. SzostakiD· 2 shared Alok Apan SwatiputraiD· 1 shared Priyanka GuptaiD· 1 shared Yamuna KrishnaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersBiochemistry

Filip BoškovićORCID

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2 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedJun 29, 2026

A nucleic acid labeling chemistry reveals surface DNA on exosomes

Filip Bošković, Priyanka Gupta, Jian Zhang…·Jack W. Szostak

The paper introduces RUNA, a reversible labeling chemistry to distinguish surface DNA from intracellular DNA on exosomes, revealing its role in immune cell interaction.

2 citations

humanDNA methylation

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BiochemistryJournal of the American Chemical SocietyPeer-reviewedMar 30, 2026

Influence of phosphate activation chemistry on the selection of the primordial genetic alphabet

Filip Bošković, Jian Zhang, Alok Apan Swatiputra, Jack W. Szostak

This study compares two phosphate-activation chemistries' effects on nucleotide modifications, showing that primordial nucleotides are more susceptible to modification, which may explain the selection of the canonical genetic alphabet.

2 citationstop 4%

experimental assay

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