Author

Jef K. De Brabander

The University of Texas Southwestern Medical CenterORCID 0000-0001-8816-5798Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:electronic health records· 1 Assay:proteomics· 1

Frequent Co-Authors

Noelle Sevilir WilliamsiD· 2 shared Alok RanjaniD· 1 shared Arin B. AuroraiD· 1 shared Ashley Leach· 1 shared Daniel M. RosenbaumiD· 1 shared Deepak NijhawaniD· 1 shared Divya ReddyiD· 1 shared Holly H. Guo· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Noelle Sevilir WilliamsORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 31, 2025

A small molecule inhibitor of NVL suppresses tumor growth by blocking ribosome biogenesis

Holly H. Guo, Ye Tao, Victor Emmanuel Cruz…·Deepak Nijhawan

The paper identifies NVL as a target for cancer therapy, showing that its inhibition by MM17 and MM927 suppresses tumor growth through ribosome biogenesis disruption.

DOI 10.1101/2025.07.31.667081

mouseproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 9, 2022

Evaluation of the Efficacy of the Hypocretin/orexin Receptor Agonists TAK-925 and ARN-776 in Narcoleptic Orexin/tTA; TetO-DTA Mice

Yu Sun, Alok Ranjan, Ryan K. Tisdale…·Thomas S. Kilduff

This study evaluates the efficacy of TAK-925 and ARN-776, HCRTR2 agonists, in reducing cataplexy and promoting wakefulness in narcoleptic mice.

DOI 10.1101/2022.12.09.519796

mouseelectronic health records

𝕏 PostBluesky