Milad Ibrahim

The paper identifies progranulin as a mediator of immune suppressive niches in brain metastasis using cross-species spatial transcriptomics and functional analyses.

The paper shows that patient-derived IgG from those with severe immune-related colitis amplifies inflammation during immune checkpoint blockade in humanized FcγR mice.

The paper identifies a lymphatic circuit that sustains stem-like CD8+ T cells by recycling tumor-experienced effector T cells, enhancing immune surveillance and ICB response.

This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.

This study identifies immune niches in NF1 mutant melanoma that promote immune evasion and shows EGFR inhibition can restore immune responses.

This study examines AMBRA1's role in melanoma by analyzing transcriptomic changes from overexpression and knock-down, identifying novel cancer-related pathways and tumor suppressor functions.

This study identifies CNDP1 as a metabolic vulnerability in brain metastasis, showing its inhibition suppresses metastasis and its expression confers metastatic potential.