Author

Kenneth Ehses

Universitätsmedizin GöttingenORCID 0000-0002-8595-5994Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Rubén Fernández‐BusnadiegoiD· 2 shared Abdussalam AzemiD· 1 shared Anja DeiseriD· 1 shared Barbara HummeliD· 1 shared Carina Fernandez GonzaleziD· 1 shared F. Ulrich HartliD· 1 shared Hauke HolthuseniD· 1 shared Iban Ubarretxena‐BelandiaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Rubén Fernández‐BusnadiegoORCID

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2 papers

Recent·Most cited

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress

Kenneth Ehses, Jorge Pedro López-Alonso, Odetta Antico, Yannik Lang, Till Rudack, Abdussalam Azem, Miratul M. K. Muqit, Iban Ubarretxena‐Belandia, Rubén Fernández‐Busnadiego

The paper uses cryo-electron tomography to study structural changes in mitochondrial protein biogenesis under proteostatic stress, revealing remodeling of cristae and mHsp60 conformation.

Science Advances · Mar 4, 2026Peer-reviewedCell Biology

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

Hauke Holthusen, Victoria A. Trinkaus, Carina Fernandez Gonzalez, Itika Saha, Isabelle Pachmayr, Orsolya Kimbu Wade, Anja Deiser, Barbara Hummel, Patricia Yuste‐Checa, Kenneth Ehses, Roman Körner, Rubén Fernández‐Busnadiego, Ritwick Sawarkar, Ralf Jungmann, Mark S. Hipp, F. Ulrich Hartl

This study shows that proteostatic stress in mitochondria impairs mitoribosome biogenesis and translation, leading to respiratory deficiency and mitochondrial DNA loss.

bioRxiv · Sep 5, 2025 · PreprintCell Biology