Frank Brombacher

This study investigates the role of PKCδ in macrophage immunomodulation during Mtb infection, finding that its deficiency leads to increased Mtb burden and exacerbated pathology.

The paper identifies widespread transcription initiation at microsatellites across species and develops deep learning models to predict STR-associated transcription and its impact on disease variants.

The paper functionally annotates human long non-coding RNAs by systematically knocking down 285 lncRNAs and analyzing molecular phenotypes using CAGE sequencing.

The paper identifies transcriptionally induced enhancers in macrophages infected with Mycobacterium tuberculosis and links them to immune gene activation.

This study shows HIV-1 evades apoptosis in macrophages by manipulating the MAP2K1/ERK2 pathway to dysregulate lincRNA-p21, and suggests MAP2K1/ERK2 inhibitors as a therapeutic strategy.

The paper identifies transcribed enhancers in mouse macrophages during activation and shows their association with gene expression and inflammation-related transcription factors.

IRNdb is a database of immunologically relevant non-coding RNAs that integrates experimentally supported interactions and annotations to aid in studying ncRNA regulation in the immune system.