Viral apoptosis evasion via the MAPK pathway by use of a host long noncoding RNA
Samantha Barichievy, Jerolen Naidoo, Mikaël Boullé, Janine Scholefield, Suraj P. Parihar, Anna K. Coussens, Frank Brombacher, Alex Sigal, Musa M. Mhlanga
This study shows HIV-1 evades apoptosis in macrophages by manipulating the MAP2K1/ERK2 pathway to dysregulate lincRNA-p21, and suggests MAP2K1/ERK2 inhibitors as a therapeutic strategy.
Frontiers in Cellular and Infection Microbiology · Aug 3, 2018Peer-reviewedMolecular Biology