Joseph G. Jardine

This paper describes the directed evolution of an antibody to enhance its binding affinity for MERS-CoV, resulting in cross-neutralization against multiple betacoronaviruses.

The paper develops a synthetic Fab yeast display library integrated with machine learning to discover antibodies against cell surface antigens, yielding hundreds of validated antibodies and a public dataset.

This study improves HIV broadly neutralizing antibodies through multistate engineering, resulting in enhanced breadth and potency against diverse Env variants.

This study shows combining a RhCMV/SIV vaccine with neutralizing antibodies enhances protection against SIV challenge in rhesus macaques.

This study engineers an HIV broadly neutralizing antibody to improve its potency, antiviral activity, and manufacturability while maintaining safety and efficacy.