Sakeen W. Kashem

The paper develops an automated image analysis pipeline to quantify cutaneous innervation in different skin compartments, revealing age and microbial effects on nerve area and length.

This study identifies meningeal regulatory T cells (mTregs) expressing enkephalin that modulate mechanical pain sensitivity in female mice via a sex hormone-dependent opioid receptor mechanism.

This study shows that silencing CCR2 in sensory neurons blocks bone cancer progression and alleviates pain by disrupting neuropeptide-driven tumor growth.

The paper shows that CCR2-targeting pepducin PP101 reduces bone cancer pain by inhibiting T cell infiltration and neuroimmune communication in dorsal root ganglia without adverse effects.

The paper shows that overexpression of tetracycline transactivator in keratinocytes causes neuropathic itch in mice, which can be reversed by inhibiting Gi signaling or ablating TRPV1 neurons.