Author

Zephan Melville

Columbia University Irving Medical CenterORCID 0000-0001-8962-2612Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alex de MarcoiD· 1 shared Amédée des GeorgesiD· 1 shared Andreas HoengeriD· 1 shared Andrew R. MarksiD· 1 shared Ash WeieriD· 1 shared Edward T. EngiD· 1 shared Elliot T Morgan· 1 shared Fabio A Vigil· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

Alex de MarcoORCID

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2 papers

Recent·Most cited

BiophysicsNature CommunicationsPeer-reviewedSep 4, 2026

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Kookjoo Kim, Huan Li, Qi Yuan…·Oliver B. Clarke

This study identifies the RY12 domain of RyR1 as an ADP sensor and reveals dantrolene's binding mechanism through cryo-EM structures.

5 citations

𝕏 PostBluesky

BiophysicsCell Reports MethodsPeer-reviewedSep 1, 2026

Cryoprotectants-assisted plunge freezing of thick brain tissue specimens for targeted physiologically relevant cryo-imaging in situ

Ash Weier, Fei Gao, Elliot T Morgan…·Oleg V. Klykov

This paper develops a cryoprotectant-assisted plunge freezing method for preserving thick mouse brain tissue for cryo-imaging, enabling high-resolution visualization of cellular structures and validating their physiological relevance.

1 citation

𝕏 PostBluesky