Najah L. Walton

Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis

This study shows that both direct and witnessed trauma reduce allopregnanolone levels and impair fear regulation in mice, suggesting neurosteroid deficits contribute to PTSD-like behaviors.

Experience-dependent information routing through the basolateral amygdala

This study shows that prior positive or negative experiences alter the activity of specific BLA neurons, affecting valence processing by biasing information routing.

Impaired endogenous neurosteroid signaling contributes to behavioral deficits associated with chronic stress

This study shows chronic stress impairs endogenous neurosteroid signaling in the BLA, leading to behavioral deficits, and suggests targeting neurosteroidogenesis could be a new treatment for mood disorders.

Allopregnanolone mediates affective switching through modulation of oscillatory states in the basolateral amygdala

This study shows allopregnanolone modulates oscillatory states in the basolateral amygdala through delta-containing GABAA receptors, contributing to antidepressant effects.