Naito Ishimoto

This study determines how MRP2 recognizes diverse drugs structurally, showing overlapping ligand binding with different interactions.

The paper shows that pilin cyclisation and pilus formation are robust to amino acid substitutions, but electrostatic changes impair conjugation efficiency.

The paper reports the cryo-EM structure of the RP4 conjugation pilus, revealing it is functional without phospholipid modification, challenging previous assumptions about pilus biogenesis.

The paper reports the cryo-EM structure of the H-pilus, revealing its cyclic pilin subunit and explaining its role in conjugation.

The paper determines the cryo-EM structure of TraT proteins from plasmids and reveals their evolutionary history, showing independent acquisition by different plasmid backbones.