Javier Martínez‐Useros

This study identifies c-Rel as a driver of pancreatic cancer metastasis by promoting EMT, ECM remodeling, and resistance to isolation stress through fibronectin-integrin signaling.

The paper identifies distinct gene expression programs driven by MITF, TFEB, and TFE3 in melanoma, revealing their functional specialization in regulating differentiation, metabolism, and immune infiltration.

This paper evaluates combining FOLFIRINOX with GPX4 inhibition to induce ferroptosis in pancreatic cancer, identifying redox-based biomarkers for treatment stratification.

This study shows that glycogen storage and metabolic buffering suppress phenotype switching in melanoma, with low glycogen levels linked to invasion and poor survival.

This study shows that vitamin D inhibits the Wnt/β-catenin pathway in colon cancer cells by activating SIRT1, which deacetylates and excludes β-catenin from the nucleus, reducing tumor growth.