Custodia García‐Jiménez

The paper identifies distinct gene expression programs driven by MITF, TFEB, and TFE3 in melanoma, revealing their functional specialization in regulating differentiation, metabolism, and immune infiltration.

This study shows that glycogen storage and metabolic buffering suppress phenotype switching in melanoma, with low glycogen levels linked to invasion and poor survival.

The paper shows that MITFLow melanoma cells uptake fatty acids from adipocytes, activating AXL and CAV1 to drive beta-catenin nuclear accumulation, promoting invasion.

This study shows that vitamin D inhibits the Wnt/β-catenin pathway in colon cancer cells by activating SIRT1, which deacetylates and excludes β-catenin from the nucleus, reducing tumor growth.