Author

María Jesús Fernández‐Aceñero

Hospital Clínico San CarlosORCID 0000-0002-2439-3553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Javier Martínez‐UserosiD· 3 shared Alexandra BerningeriD· 1 shared Ana Chocarro‐CalvoiD· 1 shared Ana Ramírez-SáncheziD· 1 shared Ángela SaéziD· 1 shared Aránzazu Cruz‐AdaliaiD· 1 shared Bruno SáinziD· 1 shared C. Dai· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCancer Biology

Javier Martínez‐UserosORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation

D. Bakırdöğen, Kıvanç Görgülü, J. Xin, L. Richter, Sonia Alcalá, Laura Ruíz-Cañas, C. Dai, Katrin J. Frank, Nan Wu, Kalliope Nina Diakopoulos, H. Ozturk, Deniz Demircioğlu, Katja Peschke, R. Ranjan, Francesca Fusco, , Hana Algül

This study identifies c-Rel as a driver of pancreatic cancer metastasis by promoting EMT, ECM remodeling, and resistance to isolation stress through fibronectin-integrin signaling.

Molecular Cancer · Dec 15, 2025Peer-reviewedCancer Biology

FOLFIRINOX Combined with GPX4 Inhibition Induces Ferroptosis and Defines Redox-Based Therapeutic Subgroups in Pancreatic Cancer

Carlos Lacalle-González, Carlos Lopez-Blazquez, Miguel Ángel Hidalgo-León, Michael Ochieng’ Otieno, Lara Sanz-Criado, María Jesús Fernández‐Aceñero, Luis M Ortega, Jesús García‐Foncillas, Javier Martínez‐Useros

This paper evaluates combining FOLFIRINOX with GPX4 inhibition to induce ferroptosis in pancreatic cancer, identifying redox-based biomarkers for treatment stratification.

bioRxiv · Sep 12, 2025 · PreprintCancer Biology

Metabolic buffering suppresses phenotype switching in cancer

Ana Ramírez-Sánchez, Miguel Jociles-Ortega, José Manuel García-Martínez, Irene Torrens-Martínez, Javier Martínez‐Useros, María Jesús Fernández‐Aceñero, Teresa Olmos-De Blas, Pakavarin Louphrasitthiphol, Colin R. Goding, Custodia García‐Jiménez, Ana Chocarro‐Calvo

This study shows that glycogen storage and metabolic buffering suppress phenotype switching in melanoma, with low glycogen levels linked to invasion and poor survival.

bioRxiv · Apr 7, 2025 · PreprintCancer Biology

Segmental regulation of intestinal motility by colitis and the adaptive immune system in the ileum and colon

Raquel Gómez-Bris, Pilar Rodríguez‐Rodríguez, Marina Ortega-Zapero, Santiago Ruvira, Raquel Castillo‐González, María Jesús Fernández‐Aceñero, Aránzazu Cruz‐Adalia, Ángela Saéz, Silvia Magdalena Arribas, José María González

This study investigates how colitis and the adaptive immune system regulate intestinal motility in the ileum and colon using a mouse model.

American Journal Of Pathology · Nov 17, 2024Peer-reviewedImmunology