Author

Jim E. Eyles

AstraZeneca (United Kingdom)ORCID 0000-0001-9043-4352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Angela L. Hughson· 1 shared Beatriz Fuga Rossi TeixeiraiD· 1 shared Charles SwantoniD· 1 shared Chris MooreiD· 1 shared Claire E. PillsburyiD· 1 shared David C. LinehaniD· 1 shared Deborah R. CaswelliD· 1 shared Edith M. Lord· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

Angela L. Hughson

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Local delivery of SBRT and IL-12 to Murine PDAC Tumors Modulates Hematopoiesis

Tara G Vrooman, Emily R. Quarato, Gary Hannon, Noah Salama, Maggie L. Lesch, Angela L. Hughson, Vedika S. Chandak, Nataliia Vdovichenko, Zhiming Jin, Ronald Lakony, Jian Ye, Sarah L Eckl, Sidney Lesser, Edith M. Lord, David C. Linehan, , Scott A. Gerber

This study shows that local delivery of SBRT and IL-12 to PDAC tumors in mice affects bone marrow hematopoiesis, causing both acute and long-term changes.

OncoImmunology · Jun 5, 2026Peer-reviewedImmunology

Oncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma

Sophie de Carné Trécesson, Philip East, Claire E. Pillsbury, Mariana Silva dos Santos, Hongui Cha, Emma Colliver, Tegan Gilmore, Sareena Rana, Chris Moore, Scott Lighterness, Deborah R. Caswell, Jesse Boumelha, Mona Tomaschko, Romain Baer, Jim E. Eyles, , Julian Downward

This study links oncogenic RAS activity to immune priming and adenosine-driven immune evasion in lung adenocarcinoma, showing both pro-immunogenic and immunosuppressive effects.

bioRxiv · Nov 25, 2025 · PreprintCancer Biology