Author

Tegan Gilmore

The Francis Crick InstituteORCID 0000-0002-6504-7083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Ambrosius P. SnijdersiD· 1 shared Beatriz Fuga Rossi TeixeiraiD· 1 shared Callan L BuechsenschuetziD· 1 shared Charles SwantoniD· 1 shared Chris MooreiD· 1 shared Claire E. PillsburyiD· 1 shared Claudio BussiiD· 1 shared Darryl HaywardiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperDevelopmental Biology

Ambrosius P. SnijdersORCID

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2 papers

Recent·Most cited

Oncogenic RAS activity is linked to immune priming and adenosine-driven immune evasion in lung adenocarcinoma

Sophie de Carné Trécesson, Philip East, Claire E. Pillsbury, Mariana Silva dos Santos, Hongui Cha, Emma Colliver, Tegan Gilmore, Sareena Rana, Chris Moore, Scott Lighterness, Deborah R. Caswell, Jesse Boumelha, Mona Tomaschko, Romain Baer, Jim E. Eyles, , Julian Downward

This study links oncogenic RAS activity to immune priming and adenosine-driven immune evasion in lung adenocarcinoma, showing both pro-immunogenic and immunosuppressive effects.

bioRxiv · Nov 25, 2025 · PreprintCancer Biology

Congenital heart defects in Down syndrome are caused by increased dosage of DYRK1A

Eva Lana‐Elola, Rifdat Aoidi, Miriam Llorian, Dorota Gibbins, Callan L Buechsenschuetz, Claudio Bussi, Helen R. Flynn, Tegan Gilmore, Sheona Watson-Scales, Marie Haugsten Hansen, Darryl Hayward, Ok‐Ryul Song, Véronique Brault, Yann Hérault, Emmanuel Deau, , Victor L. J. Tybulewicz

The paper shows increased DYRK1A dosage causes mitochondrial dysfunction and congenital heart defects in Down syndrome, which can be mitigated by a DYRK1A inhibitor.

bioRxiv · Sep 18, 2023 · PreprintDevelopmental Biology