Elena Camacho-Aguilar

The paper estimates the information content of developmental landscapes in two systems by integrating developmental biology, information theory, and dynamical systems.

This study shows that juxtaposing amnion-like cells with human pluripotent stem cells initiates gastrulation behaviors, including primitive streak formation and mesendodermal differentiation.

This study shows that endogenous Nodal signaling switches Wnt's effect from posteriorization to germ layer differentiation in human pluripotent cells under geometric constraints.

The paper shows that BMP signaling in human pluripotent stem cells induces mesodermal differentiation through timed pulses rather than concentration, involving combinatorial interactions with WNT signaling.

The paper develops a data-fitted landscape model for C. elegans vulval development using Catastrophe Theory and ABC, revealing a two-step decision process controlled by EGF and Notch-Delta signals.

The paper quantifies cell fate transitions during differentiation and identifies two mechanisms for binary cell fate decisions using a statistical model and experimental data.