Author

Meritxell Sáez

Institut Químic de SarriàORCID 0000-0002-2991-3183Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 4 Organism:mouse· 3 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:trajectory inference· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

David A. J. RandiD· 4 shared James BriscoeiD· 3 shared Elena Camacho-AguilariD· 2 shared M. Joaquina DelàsiD· 2 shared Elena Costantini· 1 shared Elizabeth FinnieiD· 1 shared Elly Margaret TanakaiD· 1 shared Eric D. SiggiaiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersDevelopmental Biology

David A. J. RandORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Minimal essential requirements for neural tube self-organisation

Hannah T. Stuart, Elena Costantini, Jingkui Wang, Teresa Krammer, M. Joaquina Delàs, Manuela Melchionda, Jake Cornwall-Scoones, Gerald Schmauss, Thomas Lendl, Keisuke Ishihara, David A. J. Rand, Meritxell Sáez, Elly Margaret Tanaka, James Briscoe

The paper shows that RA induces a transient co-expression state of PAX6 and FOXA2 in neural tube organoids, leading to two opposing cell fates that determine cell-type proportions through feedback signaling.

bioRxiv · Jun 8, 2026 · PreprintDevelopmental Biology

Measuring developmental information encoded by a dynamicallandscape

Meritxell Sáez, Giorgos Minas, Elena Camacho-Aguilar, David A. J. Rand

The paper estimates the information content of developmental landscapes in two systems by integrating developmental biology, information theory, and dynamical systems.

bioRxiv · Mar 5, 2026 · PreprintDevelopmental Biology

Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data

Marine Fontaine, M. Joaquina Delàs, Meritxell Sáez, Rory J. Maizels, Elizabeth Finnie, James Briscoe, David A. J. Rand

This paper introduces a framework to model cell fate decisions using single-cell data, revealing conserved decision-making architectures across species.

bioRxiv · May 28, 2025 · PreprintDevelopmental Biology

A quantitative landscape of cell fate transitions identifies principles of cellular decision-making

Meritxell Sáez, Robert A. Blassberg, Elena Camacho-Aguilar, Eric D. Siggia, David A. J. Rand, James Briscoe

The paper quantifies cell fate transitions during differentiation and identifies two mechanisms for binary cell fate decisions using a statistical model and experimental data.

bioRxiv · Mar 11, 2021 · PreprintDevelopmental Biology