Moustafa Tarek Gabr

This study develops a TRIC-based HTS platform to identify small molecule CD28 binders, finding 12 validated candidates with micromolar affinities.

This paper discovers and validates a first-in-class small molecule inhibitor of the SLIT2/ROBO1 interaction using DNA-encoded library screening and demonstrates its functional inhibition and ADME properties.

The paper identifies two small molecule ligands for LAG-3 through virtual screening and experimental validation, with one showing cellular target engagement.

The paper designs and characterizes second-generation cyclic peptide LAG-3 inhibitors, identifying cyclic peptide 12 as the most effective with an IC50 of 4.45 µM.

This paper discovers small molecules targeting ICOS using ASMS screening and identifies key structural features for ICOS/ICOS-L inhibition.