Joshua I. Santiago

This study identifies a single mutation that enables GKRP to gain small-molecule allostery through structural co-optation, without requiring new genetic material.

This paper reconstructs extinct glucokinase (GCK) and glucokinase regulatory protein (GKRP) to study the evolutionary origins of protein regulation in vertebrate glucose homeostasis.

This study shows ComEA reversibly condenses DNA during natural transformation, first pulling DNA into the periplasm and then promoting its transport into the cytoplasm.