Carolin Freye

This study uses Topiary to reconstruct and characterize ancestral HK enzymes, revealing evolutionary changes in allosteric regulation within the HK family.

This study shows that substrate specificity in glucokinases is not linked to conformational diversity, as similar specificity ratios are observed across ancestral and extant forms with varying structural features.

This study identifies a single mutation that enables GKRP to gain small-molecule allostery through structural co-optation, without requiring new genetic material.