Cell BiologybioRxivPreprint
Distinct Proteasomal Pathways Drive Oncogenic PPM1D Activation
Ni Yan, Deumaya Shrestha, Cameron Schluter…·Peter Grant Miller
This study shows that truncating mutations in PPM1D shift its degradation pathway from ubiquitin-independent to UBR5-mediated, leading to increased PPM1D levels and oncogenic effects.
DOI 10.64898/2026.06.01.729344