Author

Andrew E. H. Elia

Broad InstituteORCID 0000-0002-7192-1806Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Eugene OhiD· 2 shared Adam Samuel SperlingiD· 1 shared Ben K. Wesley· 1 shared Ben S. WittneriD· 1 shared Cameron Schluter· 1 shared Carmen Da Silva· 1 shared Cem TanrıöveriD· 1 shared Cyrus Jin· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Eugene OhORCID

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2 papers

Recent·Most cited

Distinct Proteasomal Pathways Drive Oncogenic PPM1D Activation

Ni Yan, Deumaya Shrestha, Cameron Schluter, Cyrus Jin, Edward Wang, Carmen Da Silva, Ilaria Gritti, Nikolaos Tsopoulidis, Ruxin Yang, Adam Samuel Sperling, Jonathan M. Tsai, Andrew E. H. Elia, Eric S. Fischer, Mikolaj Michal Slabicki, Eugene Oh, Peter Grant Miller

This study shows that truncating mutations in PPM1D shift its degradation pathway from ubiquitin-independent to UBR5-mediated, leading to increased PPM1D levels and oncogenic effects.

bioRxiv · Jun 9, 2026 · PreprintCell Biology

The E3 ligase HECTD4 regulates COX-2 dependent tumor progression and metastasis

Joanna A. Vuille, Cem Tanrıöver, Ezgi Antmen, Douglas Scott Micalizzi, Richard Y. Ebright, Sambhavi Animesh, Robert Tyler Morris, Soroush Hajizadeh, Zachary J. Nicholson, Hunter C. Russell, Eric F. Zaniewski, Ben S. Wittner, Ben K. Wesley, Ji Eun Kwak, Julian Grünewald, , Daniel A. Haber

The paper identifies HECTD4 as a tumor and metastasis suppressor that targets COX-2 for degradation, with COX-2 stabilization driving pro-tumorigenic effects in breast cancer.

Proceedings of the National Academy of Sciences · Aug 6, 2025Peer-reviewedCancer Biology