Jayakrishnan Nandakumar

The paper develops a data-analysis pipeline for HT-SELEX datasets to study DNA-binding properties of telomeric proteins, showing binding preferences for G-enriched sequences and secondary structures.

This study identifies ZCWPW1 as a chromatin-based regulator of telomere architecture and meiotic chromosome movements, independent of PRDM9.

Regeneration in aging planarians reverses age-related physiological and molecular changes, restoring youthful gene expression and tissue composition.

The paper characterizes MrfB, a DEDDh exonuclease involved in repairing mitomycin C-induced DNA damage in Bacillus subtilis, revealing its structural and biochemical properties.

The paper identifies TERT rare variants in MDS patients, showing shorter telomeres, younger age at diagnosis, and worse survival, suggesting their role in MDS pathogenesis and transplant outcomes.