Author

Martin Joseph Lett

University of BaselORCID 0000-0002-7230-9264Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1

Frequent Co-Authors

Christian MittelholzeriD· 2 shared Christopher M. R. LangiD· 2 shared David HauseriD· 2 shared Enja Tatjana KipferiD· 2 shared Fabian OtteiD· 2 shared Lorena UrdaiD· 2 shared Thomas KlimkaitiD· 2 shared Yuepeng ZhangiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Christian MittelholzerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Gut archaea drive human MAIT cell responses

Natasha Fisher-Pearson, Martin Joseph Lett, Isaac W. D. Maylam, Connor S. J. Philip, Mariolina Salio, Richard J. Suckling, Robert Alan Simmons, Keir Barnbrook, Benjamin Swift, Walter Godfrey Jaoko, Freddie Kibengo, William Kilembe, Eduard Joachim Sanders, Mark Christopher Coles, Claire F. Pearson, , Jethro S. Johnson

The paper shows that gut archaea produce 5-OP-RU, which activates MAIT cells, linking archaea to human immunity.

bioRxiv · Sep 16, 2026 · PreprintImmunology

MAIT cells derived ligands signal via VEGFR2 to promote tissue repair and liver regeneration

Katia Sayaf, Martin Joseph Lett, Kate Powell, Irene Tasin, Lucy C. Garner, Aneesha Bandari, Narayan Rhamamurthy, Francesco Paolo Russo, P Klenerman, Carl-Philipp Hackstein

This study identifies VEGFA, VEGFB, and vimentin as ligands expressed by MAIT cells that signal via VEGFR2 to promote tissue repair and liver regeneration.

bioRxiv · Mar 25, 2026 · PreprintImmunology

Rapid cloning-free mutagenesis of new SARS-CoV-2 variants using a novel reverse genetics platform

Enja Tatjana Kipfer, David Hauser, Martin Joseph Lett, Fabian Otte, Lorena Urda, Yuepeng Zhang, Christopher M. R. Lang, Mohamed Chami, Christian Mittelholzer, Thomas Klimkait

The paper introduces a cloning-free reverse genetics platform for rapidly engineering SARS-CoV-2 variants and applies it to rescue Chikungunya and Dengue viruses.

eLife · Aug 11, 2023Peer-reviewedMolecular Biology

Single-cycle SARS-CoV-2 vaccine elicits high protection and sterilizing immunity in hamsters

Martin Joseph Lett, Fabian Otte, David Hauser, Jacob Schön, Enja Tatjana Kipfer, Donata Hoffmann, Nico Joël Halwe, Lorenz Ulrich, Yuepeng Zhang, Vladimir Cmiljanović, Claudia Wylezich, Lorena Urda, Christopher M. R. Lang, Martin Beer, Christian Mittelholzer, Thomas Klimkait

This study develops a single-cycle SARS-CoV-2 vaccine that provides full protection and sterilizing immunity in hamsters against autologous challenge.

bioRxiv · May 17, 2023 · PreprintMolecular Biology