Author

Richard J. Suckling

Immunocore (United Kingdom)ORCID 0000-0002-6962-6533Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Assay:metagenomics· 1

Frequent Co-Authors

Mariolina SalioiD· 2 shared Alex LookiD· 1 shared Ali RoghanianiD· 1 shared Andrew Chancellor· 1 shared Andrew WhiteiD· 1 shared Benjamin Swift· 1 shared Bogusława KoronaiD· 1 shared Bruno LinclauiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

Mariolina SalioORCID

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3 papers

Recent·Most cited

Gut archaea drive human MAIT cell responses

Natasha Fisher-Pearson, Martin Joseph Lett, Isaac W. D. Maylam, Connor S. J. Philip, Mariolina Salio, Richard J. Suckling, Robert Alan Simmons, Keir Barnbrook, Benjamin Swift, Walter Godfrey Jaoko, Freddie Kibengo, William Kilembe, Eduard Joachim Sanders, Mark Christopher Coles, Claire F. Pearson, , Jethro S. Johnson

The paper shows that gut archaea produce 5-OP-RU, which activates MAIT cells, linking archaea to human immunity.

bioRxiv · Sep 16, 2026 · PreprintImmunology

Ligand-responsive groove remodelling in human and macaque CD1d reveals a conserved MHC-like gating mechanism

Daniel J. Burns, Alex Look, Steven Turner, Martin Maly, Oliver J. Melling, Kinga Niedobecka, Rita Szoke‐Kovacs, Hatice Nurdan Aksoy Kilinc, Richard J. Suckling, Andrew Chancellor, Mariolina Salio, Andrew White, Sally A. Sharpe, Ali Roghanian, Bruno Linclau, , Salah Mansour

This study determines the crystal structures of human and macaque CD1d bound to -GalCer, revealing conserved ligand-responsive conformational flexibility at Phe84 that modulates antigen presentation.

bioRxiv · Dec 25, 2025 · PreprintImmunology

Delta C2 Domain β1-2 loop contributes to robust Notch signalling

Torcato Martins, Yao Meng, Bogusława Korona, Richard J. Suckling, Steven Johnson, Penny A. Handford, Susan M. Lea, Sarah J. Bray

The paper shows that the Delta C2 domain β1-2 loop is essential for phospholipid binding and robust Notch signaling in Drosophila.

EMBO Reports · Aug 4, 2021Peer-reviewedDevelopmental Biology