Cancer BiologybioRxivPreprint
Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation
Tyrone Dowdy, Helena Muley, Adrian Lita…·Mioara Larion
This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.
DOI 10.1101/2024.04.26.591321