Stefano Luca Sensi

Analysis of the off-target interaction of amyloid PET tracers with human brain sulfotransferases

The paper investigates off-target interactions of amyloid PET tracers with brain sulfotransferases using multi-omic and computational methods, revealing enzyme-specific binding dynamics and implications for PET signal variability.

A Shared Entropic Axis Spans States of Consciousness Across Pharmacological and Clinical Conditions

The paper quantifies consciousness states using entropy across pharmacological and clinical fMRI data, finding a shared entropic axis spanning from low-entropy anaesthesia to high-entropy psychedelic and schizophrenia states.

Off-target interaction of the amyloid PET imaging tracer PiB with acetylcholinesterase

This study shows that the amyloid PET tracer PiB interacts with acetylcholinesterase, potentially affecting PET signal interpretation in Alzheimer's disease.

ER and SOCE Ca2+ signals are not required for directed cell migration in human microglia

This study shows that ER and SOCE Ca2+ signals are not required for directed migration of human microglia in response to purinergic stimuli, suggesting a Ca2+-independent mechanism involving cyclic AMP.

Mapping Pharmacologically-induced Functional Reorganisation onto the Brain's Neurotransmitter Landscape

This study maps how pharmacological drugs alter brain function by linking neurotransmitter receptor distribution with drug-induced changes in functional MRI connectivity.

Long-term dynamic changes of NMDA receptors following an excitotoxic challenge

The paper investigates how NMDA receptors in nNOS (+) neurons change over time after excitotoxic stress, revealing redox-driven adaptations that reduce neuronal vulnerability.

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

This study shows that TREM2 loss in human iPSC-derived microglia leads to altered Ca2+ signaling and motility via purinergic receptor pathways.

Inhibition of de novo ceramide biosynthesis affects aging phenotype in an in vitro model of neuronal senescence

This study shows that inhibiting de novo ceramide biosynthesis with L-cycloserine improves aging-related phenotypes in cultured cortical neurons.

Functional signature of conversion in Mild Cognitive Impairment patients

The paper examines MRI patterns and functional connectivity in Alzheimer's Disease patients and identifies a functional signature in c-MCI that may indicate conversion to AD.

The pharmacological perturbation of brain zinc impairs BDNF-related signalling and the cognitive performances of young mice

This study shows that reducing brain zinc levels with clioquinol impairs memory and BDNF-related signaling in young mice.

Exenatide reverts the high-fat-diet-induced impairment of BDNF signaling and inflammatory response in an animal model of Alzheimer’s disease

This study shows exenatide improves BDNF signaling and reduces neuroinflammation in 3xTg-AD mice on a high-fat diet.