Ji Won Um

Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo

This paper introduces LATeNT, a light-activated tetanus neurotoxin that enables conditional proteolysis and inducible synaptic inhibition in vivo, with applications in neuroscience and beta cell function.

MDGA2 homozygous loss-of-function variants cause developmental and epileptic encephalopathy

This study identifies homozygous loss-of-function MDGA2 variants in individuals with developmental and epileptic encephalopathy, establishing MDGA2 as a novel gene for this condition.

Bazedoxifene rescues sexually dimorphic autistic-like abnormalities in mice carrying a biallelic MDGA1 mutation

This study shows that bazedoxifene treatment rescues ASD-like behaviors in male mice with a specific MDGA1 mutation, but not in females.

Calsyntenin-3 directly interacts with neurexins to orchestrate excitatory synapse development in the hippocampus

This study shows that Calsyntenin-3 interacts with specific neurexin variants to promote excitatory synapse development in the hippocampus.

The activity-dependent transcription factor Npas4 regulates IQSEC3 expression in somatostatin interneurons to mediate anxiety-like behavior

This study shows that Npas4 regulates IQSEC3 expression in SST interneurons, affecting GABAergic synapse function and anxiety-like behavior.

Presynaptic PTPσ organizes neurotransmitter release machinery at excitatory synapses

This study shows that presynaptic PTPσ organizes neurotransmitter release at excitatory synapses and affects anxiety-like behaviors.