Simon A. Walker

This study shows that senescent human cells secrete misfolded proteins via the endo-lysosomal system, driven by DNAJC5 and reduced intracellular proteostasis.

The paper shows NANOGP1, a duplicate of NANOG, has partial functional conservation in human naive pluripotent stem cells, contributing to pluripotency but not maintaining undifferentiated status.

This study shows that satellite repeat transcripts in mouse ESCs drive heterochromatin condensates, which are crucial for chromosome stability and nuclear organization.

This study uses live imaging and mathematical modeling to analyze ATG13 dynamics in non-selective autophagy and mitophagy, revealing distinct patterns of translocation and their relationship to mitochondrial fragment size.