Harvey E. Johnston

This study identifies CLN6 as a glycerophosphoglycerol epimerase essential for BMP biosynthesis, showing its deficiency disrupts lysosomal hydrolase homeostasis and can be reversed by BMP precursor supplementation.

This study identifies HSV-1 protein pUL56 as responsible for removing voltage-gated ion channels from neuronal plasma membranes, disrupting calcium signaling and neuronal activity.

This study identifies DYRK1B as a regulator of processing body abundance through phosphoproteomics and functional assays.

The paper introduces Ubi-SCAPE, a method to purify poly-ubiquitylated proteins with high specificity, reducing contaminants and improving reproducibility.

This study shows that senescent human cells secrete misfolded proteins via the endo-lysosomal system, driven by DNAJC5 and reduced intracellular proteostasis.