Bassem A. Hassan

This study investigates the role of Pten in radial glial progenitor lineage progression and astrocyte production during cortical development, finding that Pten loss increases astrocyte generation and disrupts growth factor signaling.

The paper identifies phosphorylation of NEUROGENIN2 as a regulator of human radial glial cell neuronal output, leading to increased production of upper-layer neurons.

This paper identifies leucovorin and dyclonine as pro-oligodendrogenic compounds through pharmacogenomic screening and validates their therapeutic potential in mouse models of myelin pathologies.

This study shows that vnd is more critical than Appl for MB axon outgrowth, with vnd acting non-autonomously.

This study shows Drosophila fruit flies spontaneously prefer larger numerical quantities and identifies a neuronal substrate for numerical cognition.

This study shows that Amyloid Precursor Protein (APP) is required for human neural stem cells to maintain a progenitor state during prolonged neurogenesis, unlike mouse NSCs where APP is dispensable.

The paper identifies TZAP as a developmental regulator of mitochondrial homeostasis critical for activity-dependent synaptic connectivity in Drosophila.

The paper identifies a novel FTSJ1 pathogenic variant and shows its role in neuron morphology and learning performance through RiboMethSeq and transcriptome analysis in human and Drosophila models.

This study identifies Tensin3 as a critical regulator of oligodendrocyte differentiation by mediating integrin-β1 survival signaling during morphological changes.

The paper shows that stochastic developmental processes explain individual wiring variation in the brain.

The paper identifies two temporally distinct roles of EGFR in coupling axonal branching to synaptic stabilization during Drosophila visual system development.

The paper shows that Notch signaling regulates the fate of cerebellar progenitors to generate both excitatory and inhibitory neurons.

The paper shows that temperature-dependent changes in synaptic partner availability lead to variable connectivity and behavior in Drosophila without affecting canonical synapse ratios.

This study investigates the role of APPL, the Drosophila homologue of APP, in neuronal survival and neuro-glial interactions, revealing its involvement in endolysosomal function and neuronal debris clearance.

The paper shows that autophagy regulates axonal filopodia kinetics, which restricts incorrect synaptic partner choice during Drosophila brain development.

The paper shows non-heritable variation in neural circuit development causes individual differences in behavior using Drosophila.

The paper presents a method to quantify gene expression in developing Drosophila eye tissue, revealing direct Ato targets and gene expression changes during photoreceptor specification.

The paper shows that changes in the temporal regulation of the eyeless gene drive sensory trade-offs between visual and olfactory organs in Drosophila species.

This study identifies a conserved signaling pathway involving Dscam1, Faf/Usp9x, and JNK that promotes axonal growth in Drosophila and mammals after CNS injury.

This study identifies post-transcriptional regulation by Cpeb1 as a mechanism enhancing CNS axonal regeneration in mice and Drosophila.