Loss of KDM6A-mediated genomic instability and metabolic reprogramming differentially regulates responses to immune checkpoint therapy and chemotherapy in bladder cancer.
Pratishtha Singh, Ranit D’Rozario, Bidisha Chakraborty, Swadhin Meher, Deblina Raychaudhuri, Aminah J. Tannir, Yang Li, Anurag Majumdar, Jessalyn Hawkins, Yun zhao Xiong, Philip L. Lorenzi, Padmanee Sharma, Kadir Caner Akdemir, Patrick Glen Pilie, Abhinav K. Jain, , Sangeeta Goswami
This study shows KDM6A mutations in bladder cancer improve response to immune checkpoint therapy but worsen chemotherapy outcomes through effects on DNA repair and metabolic reprogramming.
Nature Communications · Jan 7, 2026Peer-reviewedImmunology