Cancer BiologybioRxivPreprint
A dual mechanism of sensitivity to PLK4 inhibition by RP-1664 in neuroblastoma
Isabel Soria‐Bretones, Matias Casás‐Selves, Elliot Goodfellow…·Michal Zimmermann
This study shows neuroblastoma cells are hypersensitive to PLK4 inhibitor RP-1664 due to dual mechanisms of centriole loss and amplification, leading to cell death.
5 citations