Meng Lü

This paper introduces two novel 19F NMR probes to study tyrosine ring-flip dynamics in proteins, showing they can quantify and modulate these motions in vitro and in living cells.

This study shows that 24S-HC and 27-HC, brain cholesterol metabolites, cause neuronal dysfunction in human iPSC-derived neurons by disrupting calcium signaling, organelle function, and alpha-synuclein accumulation.

This study shows that intra-mitochondrial proteostasis influences alpha-synuclein and Aβ42 aggregation, while mitochondrial stress factors like complex I inhibition do not affect these pathologies.