Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons
Yuqing Feng, Bismoy Mazumder, Tasuku Konno, Ernestine Hui, Marius Brockhoff, Valentina Davì, Meng Lü, Edward Ward, Amberley D. Stephens, Wenyue Dai, Ana Fernández‐Villegas, Giuliana Fusco, Mohsen Ali Asgari, Edward Avezov, Alfonso De Simone, , Gabriele S. Kaminski Schierle
This study shows that 24S-HC and 27-HC, brain cholesterol metabolites, cause neuronal dysfunction in human iPSC-derived neurons by disrupting calcium signaling, organelle function, and alpha-synuclein accumulation.
bioRxiv · Jun 10, 2025 · PreprintNeuroscience