Author

Marius Brockhoff

University of CambridgeORCID 0009-0004-3914-2724Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:electronic health records· 2 Approach:experimental assay· 2 Approach:machine learning (classical)· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Ana Fernández‐VillegasiD· 4 shared Clemens F. KaminskiiD· 4 shared Gabriele S. Kaminski SchierleiD· 4 shared Amberley D. StephensiD· 3 shared Edward WardiD· 3 shared Nino F. LäubliiD· 3 shared Alfonso De SimoneiD· 2 shared Ernestine HuiiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersNeuroscience

Ana Fernández‐VillegasORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 22, 2026

α-Synuclein Facilitates Spontaneous Dopamine Release in a Calcium- and Phosphorylation-Dependent Manner

Yuqing Feng, Amberley D. Stephens, Pedro Vallejo Ramirez…·Gabriele S. Kaminski Schierle

This study shows α-synuclein modulates spontaneous dopamine release via calcium and phosphorylation-dependent mechanisms, independent of full-fusion recycling.

DOI 10.64898/2026.04.20.719002

experimental assay

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NeurosciencebioRxivPreprintJun 10, 2025

Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons

Yuqing Feng, Bismoy Mazumder, Tasuku Konno…·Gabriele S. Kaminski Schierle

This study shows that 24S-HC and 27-HC, brain cholesterol metabolites, cause neuronal dysfunction in human iPSC-derived neurons by disrupting calcium signaling, organelle function, and alpha-synuclein accumulation.

DOI 10.1101/2025.06.10.656594

humanexperimental assay

𝕏 PostBluesky

NeuroscienceAdvanced SciencePeer-reviewedSep 28, 2024

Graphene microelectrode arrays, 4D structured illumination microscopy, and a machine learning-based spike sorting algorithm permit the analysis of ultrastructural neuronal changes during neuronal signalling in a model of Niemann-Pick disease type C

Meng Lü, Ernestine Hui, Marius Brockhoff…·Gabriele S. Kaminski Schierle

8 citations

mouseelectronic health records

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NeurosciencebioRxivPreprintFeb 29, 2024

Machine learning-based spike sorting reveals how subneuronal concentrations of monomeric Tau cause a loss in excitatory postsynaptic currents in hippocampal neurons

Marius Brockhoff, Jakob Träuble, Sagnik Middya…·Gabriele S. Kaminski Schierle

The paper introduces PseudoSort, a machine learning algorithm for spike sorting, and applies it to MEA data from hippocampal neurons exposed to monomeric Tau, revealing its impact on neuronal activity.

1 citation

electronic health recordsmachine learning (classical)

𝕏 PostBluesky