Shaun S.X. Lim

The paper shows that astrocytic AMPAR inhibition in mouse striatal projection neurons converts glutamatergic activity into long-term depression, suggesting astrocytic glutamate sensing stabilizes synaptic strength.

The paper shows that weakening inhibitory synapses onto dopamine neurons accelerates behavioral extinction by reducing reward-omission dopamine dips.

The paper shows that somatostatin interneurons in mouse visual cortex play a greater role in stabilizing network activity with stronger sensory input and increased arousal.

The paper shows that blocking natural phasic inhibition of dopamine neurons accelerates extinction learning and benefits perseverative mice.

The paper introduces DART.2, a method for cell-specific drug delivery, demonstrating robust bidirectional editing of neurotransmission in mice.