Michael R. Tadross

An astrocytic AMPAR-dependent parity signal preserves synaptic strength

The paper shows that astrocytic AMPAR inhibition in mouse striatal projection neurons converts glutamatergic activity into long-term depression, suggesting astrocytic glutamate sensing stabilizes synaptic strength.

Connectomic dopamine-neuron disinhibition accelerates behavioral extinction

The paper shows that weakening inhibitory synapses onto dopamine neurons accelerates behavioral extinction by reducing reward-omission dopamine dips.

Subunit selective modulation of GABAA receptors using pharmacogenetically tethered neurosteroids

The paper develops a DART platform to selectively modulate GABAA receptor subunits using neurosteroids, identifying C11-linked compounds that enhance GABA currents in 4/{delta}-containing receptors.

A one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging

The paper introduces a one-step method to create cell-impermeable fluorescent HaloTag substrates for live-cell imaging and super-resolution microscopy.

Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity

The paper shows that somatostatin interneurons in mouse visual cortex play a greater role in stabilizing network activity with stronger sensory input and increased arousal.

Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens

This study shows ketamine rescues stress-induced anhedonia in mice by cell-type-specific adaptations and input-specific synaptic changes in the nucleus accumbens.

Natural phasic inhibition of dopamine neurons signals cognitive rigidity

The paper shows that blocking natural phasic inhibition of dopamine neurons accelerates extinction learning and benefits perseverative mice.

Thousandfold Cell-Specific Pharmacology of Neurotransmission

The paper introduces DART.2, a method for cell-specific drug delivery, demonstrating robust bidirectional editing of neurotransmission in mice.

Local synaptic inhibition mediates cerebellar pattern separation necessary for learned sensorimotor associations

This study shows that local synaptic inhibition in the cerebellar granule cell layer sparsens sensory responses and enables pattern separation, crucial for sensorimotor learning in mice.