Brenda C. Shields

The paper shows that astrocytic AMPAR inhibition in mouse striatal projection neurons converts glutamatergic activity into long-term depression, suggesting astrocytic glutamate sensing stabilizes synaptic strength.

The paper shows that weakening inhibitory synapses onto dopamine neurons accelerates behavioral extinction by reducing reward-omission dopamine dips.

The paper develops a DART platform to selectively modulate GABAA receptor subunits using neurosteroids, identifying C11-linked compounds that enhance GABA currents in 4/{delta}-containing receptors.

The paper introduces a one-step method to create cell-impermeable fluorescent HaloTag substrates for live-cell imaging and super-resolution microscopy.

The paper shows that somatostatin interneurons in mouse visual cortex play a greater role in stabilizing network activity with stronger sensory input and increased arousal.

This study shows ketamine rescues stress-induced anhedonia in mice by cell-type-specific adaptations and input-specific synaptic changes in the nucleus accumbens.

The paper shows that blocking natural phasic inhibition of dopamine neurons accelerates extinction learning and benefits perseverative mice.

The paper introduces DART.2, a method for cell-specific drug delivery, demonstrating robust bidirectional editing of neurotransmission in mice.

The paper constructs a transcriptomic atlas of the thalamus, revealing a single spectrum of neuronal identities that serve as molecularly-defined filters for cortical modalities.